Veterinary college farrier Travis Burns, CJF, TE, EE, FWCF of Virginia is announcing his candidacy to be the next president of the American Farrier’s Association.
Friday, December 15, 2017
Veterinary College Farrier Travis Burns Announces Candidacy for American Farrier’s Association President, Answers Questions
Veterinary college farrier Travis Burns, CJF, TE, EE, FWCF of Virginia is announcing his candidacy to be the next president of the American Farrier’s Association.
Wednesday, December 13, 2017
Beyond Navicular Disease: Racing Commissioners Call for Regulation of Bisphosphonates in Sale Horses
Portions of the following information is edited from a press release:
The Association of Racing Commissioners International (ARCI) is formally calling for the independent regulation of the breeding and sales industries, including regulation of the class of drugs known as bisphosphonates, which are approved by the US Food and Drug Administration (FDA) for the treatment of navicular disease.
Monday, December 04, 2017
Will We Ever See Norman Rockwell's Famous Blacksmith Shop Painting Again?
Frank Farrell and Jim McCann hadn’t traveled very far from home before.
The two hardest-hammering horseshoers in American art have spent most of their lives in the Berkshire hills of western Massachusetts, where they have been working at their anvils non-stop for almost 80 years. But this summer they were wrapped up and carted gently to the middle of Manhattan, to be on display before being sold to the highest bidder at a Sotheby’s fine art auction.
Friday, November 24, 2017
Clearing Dolly: Radiographs of taxidermied sheep clone's remains investigate osteoarthritis, aging
We were warned. Almost 20 years ago, skeptics and opponents of the cloning of horses and other livestock forecast musculoskeletal calamities and weaknesses. It seemed like the prophecies of doom had come true back in 2003, when reports circulated that Dolly, the famous (and first) ewe cloned in 1996, suffered from what might be considered premature aging, in the form of osteoarthritis (OA).
Now, researchers in the United Kingdom are about to clear Dolly's name and show additional evidence of normal aging in the tribe of university-cloned sheep that followed her.
Background
Reports in 2003 that Dolly, the first animal cloned from adult cells, was suffering from osteoarthritis at the age of 5½ led to considerable scientific concern and media debate over the possibility of early-onset age-related diseases in cloned animals.
Reports in 2003 that Dolly, the first animal cloned from adult cells, was suffering from osteoarthritis at the age of 5½ led to considerable scientific concern and media debate over the possibility of early-onset age-related diseases in cloned animals.
Dolly, the world's first cloned mammal from an adult cell, is on display at the National Museums of Scotland in Edinburgh. (Creative Commons file image via Wikimedia) |
However, the only formal record of OA in the original Dolly was a brief mention in a conference abstract; it reported that Dolly had OA of the left knee. In the absence of the original records two research teams decided to find out for themselves whether the concerns were justified.
Researchers to the rescue
Teams at the University of Nottingham in England and the University of Glasgow in Scotland published research last year showing that a group of eight-year-old Nottingham ‘Dollies’ had aged normally. Last week, they published further evidence, in the form of a radiographic assessment of the skeletons of Dolly herself, Bonnie (her naturally conceived daughter) and Megan and Morag (the first two animals to be cloned from differentiated cells).
Their article, Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis, has been published in the online Nature Research Open Access journal Scientific Reports. They show that the skeletons, stored in the collections of National Museums of Scotland in Edinburgh, display radiographic OA similar to that observed in naturally-conceived sheep and Nottingham’s healthy aged clones.
Nottingham’s Dolly legacy
The four Nottingham ‘Dollies’ - Debbie, Denise, Dianna and Daisy – were derived from the cell line that gave rise to Dolly. The researchers concluded that the Nottingham Dollies had aged normally with no clinical signs of OA. They had radiographic evidence of only mild or, in one case, moderate OA.
Their results, published July last year in the academic journal Nature Communications, were in apparent stark contrast to Dolly the Sheep’s diagnosis of early onset OA which led to scientific concern and media debate over the possibility of early-onset, age-related diseases in cloned animals.
The four Nottingham ‘Dollies’ - Debbie, Denise, Dianna and Daisy – were derived from the cell line that gave rise to Dolly. The researchers concluded that the Nottingham Dollies had aged normally with no clinical signs of OA. They had radiographic evidence of only mild or, in one case, moderate OA.
Their results, published July last year in the academic journal Nature Communications, were in apparent stark contrast to Dolly the Sheep’s diagnosis of early onset OA which led to scientific concern and media debate over the possibility of early-onset, age-related diseases in cloned animals.
Radiographic examinations
The researchers travelled to Edinburgh and, with special permission from Dr Andrew Kitchener, Principal Curator of Vertebrates at National Museums Scotland, undertook radiographic examinations of the skeletons of Dolly and her contemporary clones.
Professor Corr said: “We found that the prevalence and distribution of radiographic-OA was similar to that observed in naturally-conceived sheep, and our healthy aged cloned sheep. As a result we conclude that the original concerns that cloning had caused early-onset OA in Dolly were unfounded.”
More about sheep and ageing
Commercially-produced sheep are rarely kept beyond the age of 6-7 years. Their natural life expectancy rarely extends beyond 9-10 years.
The Nottingham Dollies, who would now be over 10 years of age, have been humanely euthanized but their legacy continues. Professor Sinclair and his team are currently undertaking detailed molecular studies to gain a greater insight into the aging process.
Read the Open Access article:
S. A. Corr, D. S. Gardner, S. Langley-Hobbs, M. G. Ness, A. C. Kitchener, K. D. Sinclair. Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-15902-8
Materials kindly provided by the University of Nottingham were utilized in the creation of this article.
Background on Dolly: https://www.ed.ac.uk/news/2016/dolly-celebrates-20-years
© Fran Jurga and Hoofcare Publishing; Fran Jurga's Hoof Blog is the news service for Hoofcare and Lameness Publishing. Please, no re-use of text or images on other sites or social media without permission--please link instead. (Please ask if you need help.) The Hoof Blog may be read online at the blog page, checked via RSS feed, or received via a headlines-link email (requires signup in box at top right of blog page). Use the little envelope symbol below to email this article to others. The "translator" tool in the right sidebar will convert this article (roughly) to the language of your choice. To share this article on Facebook and other social media, click on the small symbols below the labels. Be sure to "like" the Hoofcare and Lameness Facebook page and click on "get notifications" under the page's "like" button to keep up with the hoof news on Facebook.
Read the Open Access article:
S. A. Corr, D. S. Gardner, S. Langley-Hobbs, M. G. Ness, A. C. Kitchener, K. D. Sinclair. Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-15902-8
Materials kindly provided by the University of Nottingham were utilized in the creation of this article.
Background on Dolly: https://www.ed.ac.uk/news/2016/dolly-celebrates-20-years
© Fran Jurga and Hoofcare Publishing; Fran Jurga's Hoof Blog is the news service for Hoofcare and Lameness Publishing. Please, no re-use of text or images on other sites or social media without permission--please link instead. (Please ask if you need help.) The Hoof Blog may be read online at the blog page, checked via RSS feed, or received via a headlines-link email (requires signup in box at top right of blog page). Use the little envelope symbol below to email this article to others. The "translator" tool in the right sidebar will convert this article (roughly) to the language of your choice. To share this article on Facebook and other social media, click on the small symbols below the labels. Be sure to "like" the Hoofcare and Lameness Facebook page and click on "get notifications" under the page's "like" button to keep up with the hoof news on Facebook.
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Disclosure of Material Connection: The Hoof Blog (Hoofcare Publishing) has not received any direct compensation for writing this post. Hoofcare Publishing has no material connection to the brands, products, or services mentioned, other than products and services of Hoofcare Publishing. I am disclosing this in accordance with the Federal Trade Commission’s 16 CFR, Part 255: Guides Concerning the Use of Endorsements and Testimonials in Advertising.
Wednesday, November 22, 2017
Saint Clement's Twanky Dillo Day is a Lost Hoof History Holiday
The end of November may mean Thanksgiving Day in America, but in the British Isles, there is a forgotten holiday that you probably won't find on any calendar.
For hundreds of years, people celebrated St Clement's Day on November 23. But now both the holiday and the saint it celebrated are lost and long forgotten in history. Hard as it is to find out what went on, much less why it went on, this day is worth remembering for its colorful couplets, enchanting songs, and evidence to the important (and powerful) role that farriers and blacksmiths played in local matters.
Saturday, November 11, 2017
Veterans Day for a Forgotten Hero: The Farrier at Compiègne
The memory of war is harsh, but the memory of a hero's deeds often improve with age. An anonymous World War I hero is still in the books but you have to dig to find him.
World War I began on August 1, 1914 when Germany declared war on Russia. Three days later, Great Britain declared war on Germany. And three days after that, the first British troops arrived in France. They would soon become mired in one of the longest, bloodiest wars in history.
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