Showing posts with label Melody. Show all posts
Showing posts with label Melody. Show all posts

Sunday, September 25, 2011

Insulin Resistance and Equine Laminitis Research: Australia's Melody De Laat's Academic Elevator Video


Imagine the challenge laid down by the University of Queensland to its graduate researchers: give a three-minute presentation encapsulating your doctoral work. Tell an audience of everyday people from all walks of life why it matters, what it's all about. But keep it short. Can an Australian laminitis researcher describe equine metabolic syndrome in that short amount of time--using only one slide? 3-2-1...talk!

What's your elevator speech?

You have to have one.

If you're an entrepreneur, a job seeker, self-employed or just someone who doesn't want to be left in the dust of this ever-changing world, you have to have to an elevator speech. Once all you needed was a firm handshake, and a spare business card in your wallet for when you met someone. Now you need to be able to tell him or her what you do with your life and why you do it in just a few words.

You need to be able to get the message across that you're special and you're interesting and you're worth knowing/hiring/considering, and you need to say exactly why--all in the time it would take to ride a couple of floors on the elevator of a hotel or office building.

When that elevator door opens, your speech is over.

Yes, you're saying...But then there are academics. And forget engineers. Have you ever asked a researcher or engineer what he or she actually does? I know what you're thinking: Maybe there are some elevators in some coal mines in some Third World countries that would take long enough for a researcher's speech to get to the point--if there is one, that is.

But things are changing. We live in an age of pecha-kucha, the PowerPoint challenge to present your idea in 20 slides that change every 20 seconds, whether you're ready or not. It's the age of the "unconference". And the two-minute video rules, thanks to the way that YouTube has reset our attention spans.

So imagine the challenge laid down by the University of Queensland to its graduate research community: give a three-minute presentation encapsulating your doctoral work. Tell an audience of everyday people from all walks of life why it matters, what it's all about. But keep it short.


And if you get your message across? You could be the winner.

Last year, Melody De Laat answered the UQ Three Minute Thesis competition challenge with a topic related to her thesis: The Investigation of Insulin-Induced Laminitis in Horses. Her research at the Australian Equine Laminitis Research Unit (AELRU) focused on how elevated insulin levels, which occur as a result of insulin resistance, damage the sensitive lamellar (laminar) structures of the horse's foot.

And she had to do it on a huge stage, in an even bigger theater, in front of people who knew nothing about horses' feet, let alone about laminitis or insulin resistance.

“Insulin resistance is an increasingly common problem in horses. The lamellar failure, which is known as laminitis, that results as a consequence of the elevated insulin levels in the body is a painful and debilitating condition,” Melody said confidently.

“By uncovering the mechanisms involved in insulin-induced laminitis it is hoped that we will be able to reduce the morbidity and mortality rates associated with this disease.”
 
The Queensland competition was so well-received that it has been extended to other national and international universities in Australia and beyond. Master of Ceremonies for the event is the award-winning science writer and broadcaster with ABC Science Online, and regular judge on Australian ABC TV's The New Inventors, Bernie Hobbs.

I hope you enjoyed Melody's equivalent of her elevator speech. She advanced to the finals, and there are a lot more people in Australia who know a little bit about laminitis thanks to this competition and Melody's PhD.

And--Oh! Is this your floor?

One of Melody De Laat's research breakthroughs on metabolic laminitis was featured on The Hoof Blog on July 1, 2011. If you'd like to learn more, Melody De Laat will be one of four doctoral and post-doctoral researchers from the Australian Equine Laminitis Research Unit (Simon Collins, Melody De Laat, Brian Hampson and Andrew Van Eps are the team) who will accompany AELRU director Chris Pollitt to speak at the 6th International Equine Conference on Laminitis and Diseases of the Foot in West Palm Beach, Florida October 29-31. 


© Fran Jurga and Hoofcare Publishing; Fran Jurga's Hoof Blog is a between-issues news service for subscribers to Hoofcare and Lameness Journal. Please, no use without permission. You only need to ask. This blog may be read online at the blog page, checked via RSS feed, or received via a digest-type email (requires signup in box at top right of blog page). To subscribe to Hoofcare and Lameness (the journal), please visit the main site, www.hoofcare.com, where many educational products and media related to equine lameness and hoof science can be found. Questions or problems with this blog? Send email to blog@hoofcare.com.  
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Disclosure of Material Connection: I have not received any direct compensation for writing this post. I have no material connection to the brands, products, or services that I have mentioned, other than Hoofcare Publishing. I am disclosing this in accordance with the Federal Trade Commission’s 16 CFR, Part 255: Guides Concerning the Use of Endorsements and Testimonials in Advertising.

Friday, July 01, 2011

Laminitis Research: Australian Breakthrough on Insulin Function in Equine Foot

(Text published as provided)

Researchers funded by the US-based Animal Health Foundation announced June 15, 2011, that they have made a major breakthrough in understanding how the insulin form of laminitis occurs.

Drs. Melody de Laat and Chris Pollitt of the Australian Equine Laminitis Research Unit at the University of Queensland have discovered that receptors designed to receive insulin-like growth factor 1 (IGF-1) may be binding to insulin instead if horses have high levels of insulin.

This groundbreaking discovery may enable scientists to develop strategies to try to block IGF-1 receptors from receiving insulin and prevent the disease from occurring.

The receptor also has been shown to be responsible for the metastatis of malignant tumors in humans, and drugs currently are being developed to block the receptor. These drugs may be of use in trying to treat horses that are prone to laminitis from developing high levels of insulin.

Insulin is important in regulating the blood glucose within animals, but horses that have Equine Metabolic Syndrome and Cushing’s disease often have very high levels of insulin.

Pollitt and his team, funded by AHF since 1995, previously showed that high insulin is one of the major pathways that causes laminitis, but, to this point, they had not understood how.

The equine foot is very dependent on glucose for metabolism, but it is not dependent on insulin to deliver that glucose. Horses have a large number of IGF-1 receptors in their feet, but no insulin receptors. Pollitt’s team now theorizes that these IGF-1 receptors are being stimulated by insulin that mimics insulin-like growth factor 1 and is binding to these receptors.

When this happens, the laminar epitheleal cells start to proliferate. Normally these cells in the middle of the foot don’t multiply. The cells are made at the coronary band and migrate all the way down to the sole without multiplying.

This type of proliferation causes the laminae to stretch and lengthen and the weight of the horse to ruin the bond between the external hoof wall and the bone. The bone changes position, and laminitis occurs.

“We’re starting to understand the pathway of how insulin really causes laminitis,” said Dr. Don Walsh, president of the Animal Health Foundation.

Journey from coffin bone to periople in a colorful detailed super-microscopic image! Click to order!

 © Fran Jurga and Hoofcare Publishing; Fran Jurga's Hoof Blog is a between-issues news service for subscribers to Hoofcare and Lameness Journal. Please, no use without permission. You only need to ask. This blog may be read online at the blog page, checked via RSS feed, or received via a digest-type email (requires signup in box at top right of blog page). To subscribe to Hoofcare and Lameness (the journal), please visit the main site, www.hoofcare.com, where many educational products and media related to equine lameness and hoof science can be found. Questions or problems with this blog? Send email to blog@hoofcare.com.  
 
Follow Hoofcare + Lameness on Twitter: @HoofcareJournal
 
Read this blog's headlines when you "like" the Hoofcare + Lameness Facebook Page
 
 
Disclosure of Material Connection: I have not received any direct compensation for writing this post. I have no material connection to the brands, products, or services that I have mentioned, other than Hoofcare Publishing. I am disclosing this in accordance with the Federal Trade Commission’s 16 CFR, Part 255: Guides Concerning the Use of Endorsements and Testimonials in Advertising.