Fran Jurga`s Hoofcare + Lameness: Pollitt

Showing posts with label Pollitt. Show all posts

Tuesday, September 04, 2012

Paynter Watch: Top Thoroughbred Colt Diagnosed with Post-Colitis Laminitis in New York

Paynter in his stall at a vet hospital near Saratoga. (Zayat Twitter photo)

You could hear a collective moan rise from the world of Thoroughbred racing today.

Paynter has laminitis.

For the past month, the racing press has been reporting on the condition of top three-year-old colt Paynter, trained by California's Bob Baffert. Paynter is owned by Zayat Racing Stable.

After winning the Haskell Invitational at Monmouth Park in New Jersey on July 29, the colt was transferred to a New Jersey vet clinic, then released a few days later. Few details about his condition were available but it was clear that both his connections and his fans hoped to see him run in the Travers Stakes at Saratoga.

Paynter was sent to Belmont to recover and then moved to Saratoga, where he was reported to be in light training.

Paynter (turquoise cap) finished a game second in the Belmont Stakes in June and then went on to win the Haskell Invitational on July 29. (Mike Lizzi photo)

However, last week Paynter was admitted to the Upstate Equine Medical Center in nearby Schuylerville, New York. It was confirmed that the horse was suffering from colitis, a severe infection of the horse's digestive tract that involves extensive and debilitating diarrhea. Severe and sudden laminitis is a common side-effect of colitis in horses.

A moving tribute to the colt spontaneously erupted on Twitter as hundreds of people tweeted the mantra-like hashtag, "#PowerupPaynter" throughout the weekend.

It seemed like a miracle when, on Monday, the owners tweeted that the horse was improving.

In what might be a new trend for news gatherers in horse sports, the horse's condition has been reported via the Twitter accounts of Justin and Ahmed Zayat.

Earlier this afternoon, Justin's flying fingers tweeted, in poignant 140-character bursts:

"Unfortunately we have a very sick horse who has developed serious complications in the last 24 hours.

"Other than fighting bravely his colitis, he continues to have diarrhea as well as his protein blood level is very low. We continue to give him plasma to help him out. His blood work continues to be good as well as his temp so on a standalone basis he is fighting bravely and hard...

"...He is developing a new issue about his veins being swollen, a disease that is called DIC which stands for 'disseminated intravascular coagulopathy'.

"...The most concerning news is as of last night he started becoming sore on his left foot and was scared to turn around and walk on it..unfortunately we only thought it was some swelling...but it has worsened because today he has been diagnosed with our nightmare scenario of laminitis.

"...It seems it is rapidly progressing after...additional x-rays of the foot and discussing with some foot experts, Dr. Laura (Javsicas) (has) found out that he has developed it in three of his four legs, which is heartbreaking.

"...Poor Paynter, I don't know how long he can fight this out so bravely without having pain and suffering. So far (Dr. Laura) is very conscious of that and having his pain under control.

"But we need to look at all these problems. My deep concern is that if he is a healthy horse he can fight laminitis since it is the beginning but to be a sick horse and fight all these issues all at once, it is asking for too much.

"We need to be compassionate and merciful and treat our star with the respect and love that he deserves while giving him the best chance in fighting for his life."

The prognosis for horses suffering from colitis is grim. Acute post-colitis laminitis can be especially sudden and severe and bears little resemblance to laminitis seen in otherwise healthy horses.

Ice baths have been documented in Australian Equine Laminitis Research Unit studies to prevent laminitis in horses with colitis. As described by Mark Andrews MRCVS in Equine Sciene Update,

"One treatment that (Dr. Chris) Pollitt has shown to be effective in preventing laminitis is cryotherapy, using iced water....

"'It is important that the ice water comes up to just below the knee. If only the foot is cooled laminitis still occurs.

"'We don't yet know how long this protective effect would last. But horses with toxic colitis (which often causes laminitis) have been treated successfully with an ice-water bath. The clinicians involved believe that it has prevented laminitis.'"

Paynter appears to be wearing ice boots on his legs.

To learn more:

Laminitis: What treatment at what stage? by Dr. Chris Pollitt (sign-in required)

Pharmacy sued over horse deaths at Saratoga

Veterinary Report for Miners Frolic: European Champion Event Horse “Stable But Seriously Ill” (London Olympic silver medalist event horse Miner's Frolic survived colitis a year ago and returned to competition)

Slide show of a post-colitis laminitis case in the care of farrier Adam Whitehead

Good article explaining colitis

Brush up on equine foot anatomy with innovate 3-D animated images. Order now!

© Fran Jurga and Hoofcare Publishing; Fran Jurga's Hoof Blog is a between-issues news service for subscribers to Hoofcare and Lameness Journal. Please, no use without permission. You only need to ask. This blog may be read online at the blog page, checked via RSS feed, or received via a digest-type email (requires signup in box at top right of blog page). To subscribe to Hoofcare and Lameness (the journal), please visit the main site, www.hoofcare.com, where many educational products and media related to equine lameness and hoof science can be found. Questions or problems with this blog? Send email to blog@hoofcare.com.

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Disclosure of Material Connection: I have not received any direct compensation for writing this post. I have no material connection to the brands, products, or services that I have mentioned, other than Hoofcare Publishing. I am disclosing this in accordance with the Federal Trade Commission’s 16 CFR, Part 255: Guides Concerning the Use of Endorsements and Testimonials in Advertising.

Wednesday, July 04, 2012

Laminitis: Video Lecture on Metabolic Pathway for Hoof Blog Readers

Please allow sufficient time for this video to load.

Settle down...You needed to get out of the heat anyway. Take an hour to catch up on the latest information about laminitis, with a special emphasis on insulin resistance and Equine Metabolic Syndrome.

What this is: a one-hour video Powerpoint lecture by Dr. Don Walsh on the latest research and horse management information related to laminitis, primarily via the metabolic pathway common in pleasure horses. A preliminary explanation of the septis-related form of laminitis is provided to differentiate between the two main forms of the disease.

Thanks to EquiSearch.com and EQUUS magazine for hosting "Laminitis Lessons: A Webinar for Every Horse Owner" with The Animal Health Foundation's Don Walsh, DVM, and for making this video archive available to readers of The Hoof Blog.

Dr. Walsh

The Foundation is a leading funder of laminitis research and education around the world; it relies solely on donations from individual horse owners and horsecare professionals like you and me to fund research at Dr. Chris Pollitt's Australian Equine Laminitis Research Unit as well as at leading veterinary colleges like Cornell University's equine genetics lab and the labs of private professional researchers like Katy Watts of safergrass.org.

It's not enough just to soak up the information shared in this webinar. It's not enough even to share this video and the information in it with horse owners or horsecare professionals. Please help by sharing information about the Animal Health Foundation, too and by supporting it with your donation--no matter how small--and encouraging others to do the same.

Without a doubt, horses who have laminitis--and horses who might be risk for laminitis--have benefited from the work of the Animal Health Foundation. Directly or indirectly, you have too. Please give back; the Animal Health Foundation will put your donation to work immediately.

Click on the "Donate Online Now" button to go to the Animal Health Foundation PayPal donation page and click on the "donate" button for PayPal. Donations are fully tax-deductible in the United States and may be submitted from any country, in any currency, via a number of credit cards, any time of the day or night. Thank you.

Donation checks may be sent to:

Animal Health Foundation 3615 Bassett Rd. Pacific, MO 63069

Photo of Dr. Walsh by Julie Plaster. Thanks!

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Friday, March 16, 2012

Laminitis Research Highlights Grayson Jockey Club Foundation's Research Lists for 2012

The Grayson-Jockey Club Research Foundation announced today that the charitable organization will fund 16 projects in 2012, totaling $845,646. The research includes the launch of eight new projects, continuation of eight projects entering their second year, and the Storm Cat Career Development Award.

Of special interest is the announcement that a project on laminitis has received the Elastikon™ Equine Research Award. This is funded in part through a contribution by Johnson & Johnson’s Consumer Products Company, manufacturer of Elastikon tape and other equine products.

Of particular interest are the following projects:

LAMINITIS STUDIES

1. Digital Hypothermia in Laminitis: Timing and Signaling
Dr. James Belknap, The Ohio State University (Second Year)

Dr. Belknap

The most recent figures from a study involving the USDA and State Veterinary Medical Officers project that at any given time laminitis affects 8 of every 1,000 horses in the United States. Based on the American Horse Council survey that there are 9.5 million horses in the nation, that would indicate 76,000 horses being affected at any given time. Of those affected, the USDA survey found that 4.7% died or were euthanized, or about 3,572 deaths from laminitis annually.

The authors of this project report that “an integrated research effort over the last decade has enhanced the current understanding of the pathophysiology of equine sepsis-related laminitis (one of numerous causes of the disease). This has mirrored progression of sepsis research in human medicine by moving from (an earlier) concept . . .to determining that a marked inflammatory injury takes place and is likely to play a prominent role in tissue injury and subsequent failure.” However, there have been persistent failure of systemic therapies for organ/laminar injury in both human and equine medicine. One advantage laminitis presents is that it effects the hoof rather than visceral organs, lending itself to artificial cooling more readily.

In a present project funded by the Foundation, digital hypothermia (cooling of the hoof) prior to onset of carbohydrate overload-induced equine sepsis resulted in dramatic decrease in laminar inflammatory signaling. The next goal is to find pharmaceutical therapies which can accomplish the same without the cumbersome aspects of maintaining constant hypothermia to the equine hoof (hooves).

2. Laminar Energy Failure in Supporting-Limb Laminitis
Dr. Andrew Van Eps, University of Queensland (Second Year)

Dr. Van Eps

Dr. Pollitt

This project is headed by a young researcher, Dr Andrew Van Eps, but the co-investigators are world renowned Drs. Dean Richardson and Chris Pollitt.

The project involves testing the hypothesis that supporting-limb laminitis is a result of reduced blood supply to the connection between hoof and bone (lamellar tissue). Further, that the blood supply in normal circumstances is encouraged by a regular loading and unloading of the legs and hooves (alternating which one is bearing the most weight). Injury to one leg interrupts that alternating pattern.

Dr. Richardson

The researchers will test the hypothesis with a state of the art, minimally invasive technique known as tissue microdialysis in conjunction with three dimensional computed tomography to develop effective methods of preventing or minimizing lamellar tissue energy failure. Comments in the Research Advisory Committee evaluations included “may well provide immediately applicable strategies to prevent supporting-limb laminitis” and “really nice grant, new idea about a devastating problem.”

Support-limb laminitis is a special area of research interest for the researchers funded by the Grayson Jockey Club Foundation. It is believed to be a unique form of the disease that is precipitated by prolonged weightbearing on one hind limb or one front limb, caused by the opposite (injured) limb's inability to bear weight after surgery or injury. Tragically, the overburdened "good" or "supporting" limb develops laminitis in this scenario. (Hoofcare + Lameness photo)

3. Laminar Signaling in Supporting-Limb Laminitis
Dr. James Belknap, The Ohio State University– First Year (2 Year Grant)

A recent USDA study indicates that approximately 1% of all horses in the USA suffer from laminitis at any given time, and approximately 5% of those animals die or are euthanized while many others remain crippled. Of the conditions which create laminitis, the development of the disease in the supporting limb of an already injured horse is one of the worst, since it is believed that 50% of those cases result in euthanasia.

The author reports that while there are hundreds of published papers in the literature about other forms of laminitis, reports on supporting-limb laminitis are restricted to clinical reports and case studies.

This project will “introduce a novel, non-painful model of supporting-limb laminitis and will allow for cutting edge bench research techniques to not only (1) test the current hypotheses on the cause of laminar failure, but also (2) provide an unbiased technique to determine the cellular events that occur . . .”

The investigator has performed a number of laminitis project for Grayson and the USDA, and has a well developed set of tools and techniques including laser micro-dissection of frozen laminar cells and an advanced “functional genomic” technique called RNA-Seq. By applying these techniques that have previously characterized laminitis caused by sepsis or metabolic syndrome to support limb laminitis, we will get our first understanding of what kind of drugs and treaments might prevent it.

This grant was selected by the board to receive the sixth annual Elastikon™ Equine Research Award.

4. Stem Cell Homing after IV Regional Limb Perfusion
Dr. Alan Nixon, Cornell University (First Year of Two-Year Grant)

Dr. Nixon

“The initial fervor associated with stem cell therapies has been tempered by mediocre clinical results,” states Dr. Nixon, long recognized as a key leader in quest to maximize use of stem cells. “More can be done, including pre-differentiation, gene-directed lineage targeting, and more efficient delivery.” This proposal will deliver by “local vein injection, to back-flow to bowed tendon and other disease conditions such as founder and traumatic arthritis.”

Transplanted cells then exert normalizing and restorative effects . . .” The long-range goal is to provide a simplified approach to stem cell therapy. We cannot do this without verification of cell homing and impact. (The project) will map stem cell distribution in the tendons, ligaments, and joints of the forelimb after direct venous injection.”

LAMENESS STUDIES

1. AAV-IRAP Gene Therapy to Prevent Osteoarthritis
Dr. Laurie Goodrich, Colorado State University (Second Year)

Dr, Goodrich

Osteoarthritis is a common affliction in horses, and current methods of treatment are effective only in reducing the pain, at best. This proposal will utilize gene therapy, which is a technique in which cells can be genetically modified or “re-programmed” to produce beneficial protein that will allow cartilage to heal. The initials in the project title stand for Adenoassociated Virus and Interluken Receptor Antagonist Protein. If cells in the joint could be re-programmed to produce IRAP, the devastating effects of joint inflammation could be halted and the progress of osteoarthritis could be reversed.

These researchers’ preliminary work utilizing AAV-IRAP suggests that cells of joints are easily re-programmed to produce beneficial protein. The aims of this project is to define the most appropriate dose of AAV-IRAP that will result in effective levels and answer the question of whether this approach can prevent osteoarthritis in the horse.

2. Investigation of Cell and Growth-Factor Dependent Tenogenesis
Dr. Martin A. Vidal, University of California-Davis (Second Year)

Dr. Vidal

The crux of this study is to test preliminary indications that a newly developed in vitro tendon/ligament culture model will prove effective at determining the optimal cell type from bone marrow, fat tissue, umbilical cord, tendons, ligaments, and muscle to use in tendon and ligament repair. The model also will allow investigators to learn the early molecular and cellular signals in tendon and ligament tissue formation.

The author states that current methods of healing result in inferior scar tissue and re-injury rates ranging from 23% to 67%. Transforming growth factor (TGF) combined with platelet rich plasma will be utilized, and tests will be done on how they affect tissue growth, strength, and composition. ”

3. Stem Generation of Equine Induced Pluripotent Cells for Regenerative Therapy
Dr. Lisa Fortier, Cornell University (Second Year)

Dr. Fortier

Stem cell based therapies are among avenues being tested with the goal of tendon cell regeneration to address tendonitis. The types of stem cells used so far may improve the structure of tendon healing, but appear to have limited regenerative ability or are limited due to potential issues of immune rejection.

The author explains that, “ . . . this proposal is to generate induced pluripotent stem cells (iPS cells) from equine adult dermal fibroblasts. iPS cells are the only stem cells that are both pluripotenent and autogenous, making them the most useful for clinical application. The expectation is that the results of the studies in this proposal will provide the first published description of the generation and characterization of equine iPS cells.” This is part of a process of testing the overall hypothesis that equine iPS cells will enhance tendon regeneration in cases of tendonitis.

Also, “the technical expertise gained in this study could be used in the future to generate autogenous iPS cells for use in equine cartilage and neuronal regeneration studies.”

Go inside the horse's hoof...you'll be amazed what you'll see--in 3-D, too!
Thanks for ordering; the program is in stock and ready to ship!

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Sunday, September 25, 2011

Insulin Resistance and Equine Laminitis Research: Australia's Melody De Laat's Academic Elevator Video

Imagine the challenge laid down by the University of Queensland to its graduate researchers: give a three-minute presentation encapsulating your doctoral work. Tell an audience of everyday people from all walks of life why it matters, what it's all about. But keep it short. Can an Australian laminitis researcher describe equine metabolic syndrome in that short amount of time--using only one slide? 3-2-1...talk!

What's your elevator speech?

You have to have one.

If you're an entrepreneur, a job seeker, self-employed or just someone who doesn't want to be left in the dust of this ever-changing world, you have to have to an elevator speech. Once all you needed was a firm handshake, and a spare business card in your wallet for when you met someone. Now you need to be able to tell him or her what you do with your life and why you do it in just a few words.

You need to be able to get the message across that you're special and you're interesting and you're worth knowing/hiring/considering, and you need to say exactly why--all in the time it would take to ride a couple of floors on the elevator of a hotel or office building.

When that elevator door opens, your speech is over.

Yes, you're saying...But then there are academics. And forget engineers. Have you ever asked a researcher or engineer what he or she actually does? I know what you're thinking: Maybe there are some elevators in some coal mines in some Third World countries that would take long enough for a researcher's speech to get to the point--if there is one, that is.

But things are changing. We live in an age of pecha-kucha, the PowerPoint challenge to present your idea in 20 slides that change every 20 seconds, whether you're ready or not. It's the age of the "unconference". And the two-minute video rules, thanks to the way that YouTube has reset our attention spans.

So imagine the challenge laid down by the University of Queensland to its graduate research community: give a three-minute presentation encapsulating your doctoral work. Tell an audience of everyday people from all walks of life why it matters, what it's all about. But keep it short.

And if you get your message across? You could be the winner.

Last year, Melody De Laat answered the UQ Three Minute Thesis competition challenge with a topic related to her thesis: The Investigation of Insulin-Induced Laminitis in Horses. Her research at the Australian Equine Laminitis Research Unit (AELRU) focused on how elevated insulin levels, which occur as a result of insulin resistance, damage the sensitive lamellar (laminar) structures of the horse's foot.

And she had to do it on a huge stage, in an even bigger theater, in front of people who knew nothing about horses' feet, let alone about laminitis or insulin resistance.

“Insulin resistance is an increasingly common problem in horses. The lamellar failure, which is known as laminitis, that results as a consequence of the elevated insulin levels in the body is a painful and debilitating condition,” Melody said confidently.

“By uncovering the mechanisms involved in insulin-induced laminitis it is hoped that we will be able to reduce the morbidity and mortality rates associated with this disease.”

The Queensland competition was so well-received that it has been extended to other national and international universities in Australia and beyond. Master of Ceremonies for the event is the award-winning science writer and broadcaster with ABC Science Online, and regular judge on Australian ABC TV's The New Inventors, Bernie Hobbs.

I hope you enjoyed Melody's equivalent of her elevator speech. She advanced to the finals, and there are a lot more people in Australia who know a little bit about laminitis thanks to this competition and Melody's PhD.

And--Oh! Is this your floor?

One of Melody De Laat's research breakthroughs on metabolic laminitis was featured on The Hoof Blog on July 1, 2011. If you'd like to learn more, Melody De Laat will be one of four doctoral and post-doctoral researchers from the Australian Equine Laminitis Research Unit (Simon Collins, Melody De Laat, Brian Hampson and Andrew Van Eps are the team) who will accompany AELRU director Chris Pollitt to speak at the 6th International Equine Conference on Laminitis and Diseases of the Foot in West Palm Beach, Florida October 29-31.

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Friday, July 01, 2011

Laminitis Research: Australian Breakthrough on Insulin Function in Equine Foot

(Text published as provided)

Researchers funded by the US-based Animal Health Foundation announced June 15, 2011, that they have made a major breakthrough in understanding how the insulin form of laminitis occurs.

Drs. Melody de Laat and Chris Pollitt of the Australian Equine Laminitis Research Unit at the University of Queensland have discovered that receptors designed to receive insulin-like growth factor 1 (IGF-1) may be binding to insulin instead if horses have high levels of insulin.

This groundbreaking discovery may enable scientists to develop strategies to try to block IGF-1 receptors from receiving insulin and prevent the disease from occurring.

The receptor also has been shown to be responsible for the metastatis of malignant tumors in humans, and drugs currently are being developed to block the receptor. These drugs may be of use in trying to treat horses that are prone to laminitis from developing high levels of insulin.

Insulin is important in regulating the blood glucose within animals, but horses that have Equine Metabolic Syndrome and Cushing’s disease often have very high levels of insulin.

Pollitt and his team, funded by AHF since 1995, previously showed that high insulin is one of the major pathways that causes laminitis, but, to this point, they had not understood how.

The equine foot is very dependent on glucose for metabolism, but it is not dependent on insulin to deliver that glucose. Horses have a large number of IGF-1 receptors in their feet, but no insulin receptors. Pollitt’s team now theorizes that these IGF-1 receptors are being stimulated by insulin that mimics insulin-like growth factor 1 and is binding to these receptors.

When this happens, the laminar epitheleal cells start to proliferate. Normally these cells in the middle of the foot don’t multiply. The cells are made at the coronary band and migrate all the way down to the sole without multiplying.

This type of proliferation causes the laminae to stretch and lengthen and the weight of the horse to ruin the bond between the external hoof wall and the bone. The bone changes position, and laminitis occurs.

“We’re starting to understand the pathway of how insulin really causes laminitis,” said Dr. Don Walsh, president of the Animal Health Foundation.

Journey from coffin bone to periople in a colorful detailed super-microscopic image! Click to order!

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Wednesday, March 16, 2011

Grayson Laminitis Research Funding Breaks New Ground: Richardson, Pollitt and Van Eps Join Forces for International Support-Limb Laminitis Prevention Study

Today the Grayson Jockey Club Research Foundation announced its selection for the 2011 round of equine research projects that will be funded.

Laminitis research figured prominently in the mix of subjects to be studied. In particular, two studies will receive support from the Lexington, Kentucky-based charitable organization.

The first covers the dreadful form of laminitis that led to the death of 2006 Kentucky Derby winner Barbaro. This will be a multiple-year study; "first year" refers to the funding applied for 2011. Andrew van Eps received his PhD at the University of Queensland in Australia by studying laminitis; his previous contributions have included the first studies of the use of cryotherapy to prevent laminitis.

Here are the Grayson descriptions of the new studies:

Laminar Energy Failure in Supporting-Limb Laminitis

Dr. Andrew Van Eps, University of Queensland--First Year

Andrew Van Eps BVSc, PhD, MACVSc, DACVIM

A frequent and disheartening result of injury repair is that the leg opposite the one injured develops laminitis. This is known as supporting-limb laminitis and is what eventually caused Barbaro to be euthanized. Although it is a common occurrence, the mechanisms of the malady have not been established.

This project is headed by a young researcher, but the co-investigators are world renowned Drs. Dean Richardson and Chris Pollitt.

Professor Chris Pollitt BVSc, PhD

The project involves testing the hypothesis that supporting-limb laminitis is a result of reduced blood supply to the connection between hoof and bone (lamellar tissue). Further, that the blood supply in normal circumstances is encouraged by a regular loading and unloading of the legs and hooves (alternating which one is bearing the most weight). Injury to one leg interrupts that alternating pattern.

The researchers will test the hypothesis with a state of the art, minimally invasive technique known as tissue mycrodialysis in conjunction with three dimensional computed tomography to develop effective methods of preventing or minimizing lamellar tissue energy failure.

Comments in the Research Advisory Committee evaluations included “may well provide immediately applicable strategies to prevent supporting-limb laminitis” and “really nice grant, new idea about a devastating problem.”

Dr. Richardson received second-year funding for his ongoing study of laminitis:

Dr. Dean Richardson, University of Pennsylvania--Second Year

In Vivo Gene Transfer for the Treatment of Laminitis

Dean Richardson DVM, DACVS

This project seeks to develop a gene therapy approach to prevent laminitis in the contralateral hoof when a horse is being treated for a musculoskeletal injury. This, of course, was what eventually ended the efforts to save Barbaro and is a frequent threat to horses with hoof and leg injuries. The well known research team already has compelling preliminary data which encourages the hypothesis that use of recombinant adeno-associated viruses can be used as vectors to deliver a therapeutic gene (TMP-3) to the lamellar tissues. This is meant to inhibit the damage to the epidermal laminae without disrupting the normal hoof structure.

Another completely new study will begin at The Ohio State University, where the mechanism of cryotherapy in averting laminitis will be studied and, hopefully, recreated via pharmacology.

Digital Hypothermia in Laminitis: Timing and Signaling

Dr. James Belknap, The Ohio State University--First Year

The most recent figures from a study involving the USDA and State Veterinary Medical Officers project that at any given time laminitis affects 8 of every 1,000 horses in the United States. Based on the American Horse Council survey that there are 9.5 million horses in the nation, that would indicate 76,000 horses being affected at any given time. Of those affected, the USDA survey found that 4.7% died or were euthanized, or about 3,572 deaths from laminitis annually.

The authors of this project report that “an integrated research effort over the last decade has enhanced the current understanding of the pathophysiology of equine sepsis-related laminitis (one of numerous causes of the disease). This has mirrored progression of sepsis research in human medicine by moving from (an earlier) concept . . .to determining that a marked inflammatory injury takes place and is likely to play a prominent role in tissue injury and subsequent failure.”

However, there have been persistent failure of systemic therapies for organ/laminar injury in both human and equine medicine. One advantage laminitis presents is that it effects the hoof rather than visceral organs, lending itself to artificial cooling more readily. In a present project funded by the Foundation, digital hypothermia (cooling of the hoof) prior to onset of carbohydrate overload-induced equine sepsis resulted in dramatic decrease in laminar inflammatory signaling.

The next goal is to find pharmaceutical therapies which can accomplish the same without the cumbersome aspects of maintaining constant hypothermia to the equine hoof (hooves).

Click here to easy-order the poster created with the Michigan State U. Equine Foot Laboratory

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Sunday, September 27, 2009

Pollitt's Laminitis Images Have a New Look: MIMICS Software Goes 3-D

by Fran Jurga | 27 September 2009 | Fran Jurga's Hoof Blog

The cover of the Proceedings of the 2009 laminitis conference is a compilation of images of one foot of a chronic laminitis case from the University of Queensland in Australia. The foot's CT scans were converted to 3-D images using Mimics software and the expertise of Dr. Simon Collins of the Animal Health Trust in Newmarket, England. (Double-click on image for a larger view in a new window, but sorry that the web requires a low-resolution version of a very high-resolution form.)

When the end of the Fifth International Equine Conference on Laminitis and Diseases of the Foot comes, attendees might remember proportionately less of what they heard...and more of what they saw.

The heightened visual aspect of the exciting biennial conference, which will be held November 6-8 in West Palm Beach, Florida, may lie in the technology side of things, but the impact will be an eyeful that everyone can appreciate.

Leave it to Dr. Chris Pollitt (photo inset at left), assistant director of the conference, to bring the latest and greatest technology to the conference and to enhance his presentations.

The new software is called MIMICS; it is made by a Belgian company called Materialise NV. In a nutshell, MIMICS converts CT scans into three-dimensional forms. I've also seen it used to model a nasal cavity for a surgery case at Cornell's vet school, and for a comparative study of the soft tissue structures of equine feet at Auburn University. Dr. Pollitt says that MIMICS software is used extensively for human skeletal reconstruction surgery and prosthetic implant design and simulation.

"Suddenly I can 'see' an individual horse’s foot from all angles and can virtually dissect it on the computer monitor," Dr Pollitt wrote in the Proceedings.

MIMICS was introduced to Dr Pollitt and to the world of laminitis by British hoof anatomy researcher Dr Simon Collins. Dr Collins will be in Palm Beach to explain how he uses computer modeling in his work at the Animal Health Trust, where he collaborates with lameness experts Drs Rachel Murray and Sue Dyson. His images will be dazzling.

Dr Pollitt wrote in his introductory essay in the Proceedings, "Analyses of feet with chronic laminitis clearly show that distorted tubular hoof growth, lamellar wedge formation and solar loading of the distal phalanx are relentlessly destructive to bone. It behooves laminitis caregivers to understand the unmitigated, severe chronic process and develop proactive, early intervention strategies that will measurably arrest the process. MIMICS in the hands of laminitis scientists will aid this process."

Does anyone besides me see great irony in the way that Dr Pollitt over the years has created stunning visual images of the terribly destructive disease of laminitis? The quality of his images is always worthy of Scientific American or National Geographic and yet the subject is the disease we all dread. Thanks to his artistic eye we all know what laminitis looks like, even though it's the disease we'd most like to see wiped off the equine map.

NOTE: The deadline for registration for the conference has been pushed back to September 28th, since the mail has been so slow in getting the brochures and registration forms to everyone. Brochures were sent to all subscribers to Hoofcare and Lameness Journal. Also, a reduced rate for two-person registrations has been added. Visit www.laminitisconference.com for more information.

Credit: Individual cover images were created by Dr. Simon Collins of the Animal Health Trust in Newmarket, England using MIMICS software, and are used with permission; they illustrate pathology on the “Bronski” chronic laminitis case studied by Dr. Chris Pollitt at the Australian Equine Laminitis Research Unit in 2009. Cover montage and design by Fran Jurga will be published with Proceedings of the Fifth International Equine Conference on Laminitis and Diseases of the Foot in West Palm Beach, Florida November 6-8, 2009.

© Fran Jurga and Hoofcare Publishing. No use without permission. You only need to ask. Fran Jurga's Hoof Blog is a between-issues news service for subscribers to Hoofcare and Lameness Journal. This blog may be read online at the blog page, checked via RSS feed, or received via a digest-type email (requires signup in box at top right of blog page). To subscribe to Hoofcare and Lameness (the journal), please visit the main site, www.hoofcare.com, where many educational products and media related to equine lameness and hoof science can be found. Questions or problems with this blog? Send email to blog@hoofcare.com.

Monday, May 18, 2009

LAMINITIS: Proceedings Book and Disk Full of Valuable Research, Therapy, and Medicine for Reference

A montage of thermography images graces the cover of the laminitis proceedings book. The images represent 48 hours of the onset of laminitis; the colors register the relative heat of the foot. If you double-click on this image, you should be able to see it at a much larger size. Image © Dr. Chris Pollitt and Hoofcare Publishing. No use without permission.

Hoofcare and Lameness is happy to announce that a few more extra copies of the proceedings book and cd-rom from the 4th International Equine Conference on Laminitis and Diseases of the Foot, held in West Palm Beach, Florida in 2007, have been added to our listings of books and new media for your library. These are probably the last copies that will ever be sold.

The Proceedings were published by Hoofcare and Lameness summarized in a 7 x 10", 122-page full-color illustrated book describing presentations and lectures with special essays written for the book by Drs James Orsini, Rustin Moore, and Chris Pollitt.

The book is sold alone, or as part of a two part book and cd-rom package.

The cd-rom contains 76 papers, plus many images and a few PowerPoint excerpts, as provided by the faculty and edited and formated by Hoofcare and Lameness. The accompanying book contains a summary of each speaker's presentation, and color photographs.

Included are the special treats of Dr. Pollitt's "48 Hours in Acute Laminitis", as shown on the cover, as well as his previously unpublished sequential CT scans of the blood supply to the foot.

Dr. Moore's essay addresses the significance of laminitis research and education in the aftermath of the Barbaro tragedy and publicity earlier in 2007.

A few other presenters and authors included Steve Adair, James Belknap, Robert Boswell, Thomas Divers, Berndt Driessen, Lisa Fortier, Bryan Fraley, Ray Geor, Aaron Gygax, Amanda House, John Hubbell, Philip Johnson, Fran Jurga, Bruce Lyle, Joseph Mankowski, Catherine McGowan, Scott Morrison, John Peroni, Patrick Reilly, Ron Renirie, Rob Sigafoos, Mark Silverman, Nathan Slovis, Ashley Stokes, Mitch Taylor, Andrew Van Eps, Don Walsh, Kathryn Watts, Mary Beth Whitcomb, Michael Wildenstein and Laura Zarucco.

The cd-rom represents the single largest collection of papers on laminitis and diseases of the foot ever published in one place.

A table of contents for the cd-rom is available on request. Please send an email to Fran Jurga if you would like the contents to be sent to you as an email attachment.

Ordering information: Order book only or book+cd-rom package. Summary book is 7x10, 122 pages, full color. CD-ROM is Mac or Windows compatible and contains all papers in PDF or PowerPoint formats. Papers vary in length and format. All orders must be pre-paid in US dollars, Visa or MasterCard accepted. Book only is $59; Book + cd-rom package is $125 per set. Add $8 postage per book or per set for USA orders; add US$15 per book or per set to other countries.

Click here for faxable order form. Fax to 978 283 8775 or mail with check drawn on USA bank to Hoofcare, 19 Harbor Loop, Gloucester MA 01930. Email orders to Conferencebooks@hoofcare.com. Prices subject to change without notice; supplies are limited.

Conference books and cd-roms were sent to all attendees of the 2007 conference. These extra copies are being offered to libraries and interested individuals who did not attend.

The Proceedings book and cd-rom were sponsored by Intervet and created by Dr. Chris Pollitt and Fran Jurga.

The 5th International Equine Conference on Laminitis and Diseases of the Foot is being planned for November 2009 and will again be held in West Palm Beach, Florida.

© Fran Jurga and Hoofcare Publishing. No use without permission. Fran Jurga's Hoof Blog is a between-issues news service for subscribers to Hoofcare and Lameness Journal. To subscribe to Hoofcare and Lameness, please visit our main site, www.hoofcare.com, where many educational products and media related to equine lameness and hoof science can be found. This post originally appeared on September 17, 2008 at http://www.hoofcare.blogspot.com.

Thursday, May 07, 2009

Hoof Research Road Show Premieres This Weekend: Pollitt-Hampson Laminitis and Wild Horse Hooves Headline in Australia

by Fran Jurga | 7 May 2009 | Fran Jurga's Hoof Blog

Dr. Pollitt is known for his hoof-related research but part of his ability to get people to listen is his dazzling imagery. These images are from a series of CT scans of a foot. (©Chris Pollitt/AELRU image)

A couple of weeks ago, there was a street scene here in Boston that was wilder than anything since the Red Sox won the World Series. U2 was in the town. That's not so unusual in itself--the band might play Fenway Park or some other huge venue and sell it out for three or four nights of legendary concerts.

But this was different. They secretly booked a tiny concert hall in the suburb of Somerville.

I can remember, vaguely, that the Rolling Stones did something similar years ago. They wanted to play a small, intimate little theater where they could see the audience and judge how the music was received.

The same thing is going on this weekend in the southern end of Australia, where Dr. Chris Pollitt and his PhD candidate assistant Brian Hampson are quietly opening a new series of lectures on laminitis and hoof research. They'll be at the University of Melbourne Friday, and in Tasmania Sunday.

Dr. Pollitt's been lecturing about laminitis for years, but his work now has the added synergy of the brumby (wild horse) research component, which in turn has been energized by some out-of-the-box thinking about domestic vs wild horses that will have all of us scratching our heads when we finally hear these lectures.

Dr. Pollitt's model foot begins with a MIMICS image, created in collaboration with Dr Simon Collins, Animal Health Trust, Newmarket, UK

There were gasps of apprehension when Dr. Pollitt stepped down as professor at the University of Queensland vet school, but the research world was pleased. Freedom from teaching would surely allow him to dedicate full time to his directorship of the Australian Equine Laminitis Research Unit, the world's leading center for laminitis research at the University of Queensland.

To everyone's surprise, something else happened. In addition to charging forward on the laminitis front with a collaboration with the Laminitis Institute at the University of Pennsylvania, he started a second research center, the brumby unit, designed to study the hooves of Australian wild horses so that he could finally come to understand how a normal foot is supposed to function.

For years, Dr Pollitt has said that his hands have been tied in laminitis research because he is trying to understand a disease mechanism in the foot without being able to compare it to the normal functioning foot because we simply don't have a good model of the normal foot.

So Pollitt and his research associate, Brian Hampson, and most recently with sidekick American veterinarian Dr. Donald Walsh of Missouri, have been trekking through the outback of Australia studying wild horses in wet, dry, rocky, sandy and even flooded terrain. They watch, they film, they tag, they camp, they bring volunteer research assistants, and they've collect data--volumes of it, none of which has been shared except in tantalizing tidbits until now.

Donald Walsh DVM of Missouri, president of the Animal Health Foundation in Pacific, Missouri, has been conducting laminitis research in Australia but rode out on brumby research expeditions with Pollitt and Hampson. Walsh has been studying wild horse feet in the USA; the Animal Health Foundation helps fund Pollitt's laminitis research. (Brumby Research Unit Photo)

Marg Richardson, a research team member of the Australian Brumby Research Unit, is one of the hosts for the lecturers this weekend and has organized the warmup tour.

She is particularly excited to be introducing Brian Hampson in his first official speaking tour. At the Australian Brumby Research Unit, Hampson is undertaking world-leading research by capturing and sedating brumbies, attaching GPS collars, tracking their movement and then recording the relevant data for herd groups. This includes what they are eating, the condition of their hooves and how much they are moving.

One of the marketing projects launched by the Australian Brumby Research Unit is making freeze-dried brumby feet available to other researchers.

Maybe, it turns out, to understand a lot about hooves we need to learn to a little bit about behavior. “Never has the saying of ‘No Foot No Horse’ been more obvious, when you see how much these horses move,” Hampson says. “We have tracked the movement of domestic horses in a variety of settings from the racing environment (to) five-acre paddocks (and) up to 10,000 acre paddocks to see the variation of movement and it has been quite staggering. Old brood mares turned out in paddocks are moving more over a 24-hour period than our elite race horses."

Dr. Pollitt's presentations will center on using computed tomography imagery to share the inside view of what happens to the hoof in laminitis and other hoof diseases, compared to normal hooves. Digital images from the CT scans, arranged in 3-D will also allow manipulation of the model to observe whatever tissue is of interest. Models will be shown for laminitis, side bone and normal feet.

A world tour is planned, of course; Dr Pollitt plans to speak at the 5th International Equine Conference on Laminitis and Diseases of the Foot in West Palm Beach, Florida, to be held November 6-8. See you there.

It sounds like Brian Hampson is ready for a world tour of his own.

I am not positive that places are still open in the lectures, but you can inquire. Please email Marg Richardson or phone (in Australia) 64 272255 or 0419 572255. Click here for a press release and links to flyers from the Equine Veterinarians Australia web site.

To learn more, visit both The Australian Equine Laminitis Research Unit and the Australian Brumby Research Unit.