Showing posts with label Richardson. Show all posts
Showing posts with label Richardson. Show all posts

Friday, June 10, 2011

USA TODAY Laminitis Video: Penn Vet's New Bolton Center and the Legacy of Barbaro


USA Today had a terrific article yesterday about the laminitis work being done at the University of Pennsylvania's School of Veterinary Medicine's New Bolton Center. At the rural campus outside Philadelphia, 2006 Kentucky Derby winner Barbaro was a patient for about seven months while he struggled to both recover from a fractured leg suffered in the 2006 Preakness Stakes and, even more poignantly, fight laminitis.

What a nice surprise to find out that, in addition to the terrific photos and article that were actually in the newspaper, they also filmed a video at New Bolton, which we are privileged to share with you here on the Hoof Blog.

In the video, you will recognize (in order of appearance) farrier Pat Reilly, Laminitis Institute researcher Hannah Gallantino-Homer, and veterinarians Jim Orsini and Dean Richardson, all members of the staff at New Bolton Center.

The full article can be read online but the great photos are not available:
Five years after Barbaro, pains and gains

Many staff and researchers associated with New Bolton Center's Laminitis Institute will be involved in the Sixth International Equine Conference on Laminitis and Diseases of the Foot to be held October 29-31 in West Palm Beach, Florida. Visit www.laminitisconference.com for more information; the program will be announced soon.

The ONE book you need! Call 978 281 3222 to order

 © Fran Jurga and Hoofcare Publishing; Fran Jurga's Hoof Blog is a between-issues news service for subscribers to Hoofcare and Lameness Journal. Please, no use without permission. You only need to ask. This blog may be read online at the blog page, checked via RSS feed, or received via a digest-type email (requires signup in box at top right of blog page). To subscribe to Hoofcare and Lameness (the journal), please visit the main site, www.hoofcare.com, where many educational products and media related to equine lameness and hoof science can be found. Questions or problems with this blog? Send email to blog@hoofcare.com.  
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Wednesday, March 16, 2011

Grayson Laminitis Research Funding Breaks New Ground: Richardson, Pollitt and Van Eps Join Forces for International Support-Limb Laminitis Prevention Study

Today the Grayson Jockey Club Research Foundation announced its selection for the 2011 round of equine research projects that will be funded.

Laminitis research figured prominently in the mix of subjects to be studied. In particular, two studies will receive support from the Lexington, Kentucky-based charitable organization.

The first covers the dreadful form of laminitis that led to the death of 2006 Kentucky Derby winner Barbaro. This will be a multiple-year study; "first year" refers to the funding applied for 2011. Andrew van Eps received his PhD at the University of Queensland in Australia by studying laminitis; his previous contributions have included the first studies of the use of cryotherapy to prevent laminitis.

Here are the Grayson descriptions of the new studies:

Laminar Energy Failure in Supporting-Limb Laminitis
Dr. Andrew Van Eps, University of Queensland--First Year
Andrew Van Eps BVSc, PhD, MACVSc, DACVIM
A frequent and disheartening result of injury repair is that the leg opposite the one injured develops laminitis. This is known as supporting-limb laminitis and is what eventually caused Barbaro to be euthanized. Although it is a common occurrence, the mechanisms of the malady have not been established.

This project is headed by a young researcher, but the co-investigators are world renowned Drs. Dean Richardson and Chris Pollitt.

Professor Chris Pollitt BVSc, PhD
The project involves testing the hypothesis that supporting-limb laminitis is a result of reduced blood supply to the connection between hoof and bone (lamellar tissue). Further, that the blood supply in normal circumstances is encouraged by a regular loading and unloading of the legs and hooves (alternating which one is bearing the most weight). Injury to one leg interrupts that alternating pattern.

The researchers will test the hypothesis with a state of the art, minimally invasive technique known as tissue mycrodialysis in conjunction with three dimensional computed tomography to develop effective methods of preventing or minimizing lamellar tissue energy failure.

Comments in the Research Advisory Committee evaluations included “may well provide immediately applicable strategies to prevent supporting-limb laminitis” and “really nice grant, new idea about a devastating problem.”

Dr. Richardson received second-year funding for his ongoing study of laminitis:

Dr. Dean Richardson, University of Pennsylvania--Second Year
In Vivo Gene Transfer for the Treatment of Laminitis

Dean Richardson DVM, DACVS
This project seeks to develop a gene therapy approach to prevent laminitis in the contralateral hoof when a horse is being treated for a musculoskeletal injury. This, of course, was what eventually ended the efforts to save Barbaro and is a frequent threat to horses with hoof and leg injuries. The well known research team already has compelling preliminary data which encourages the hypothesis that use of recombinant adeno-associated viruses can be used as vectors to deliver a therapeutic gene (TMP-3) to the lamellar tissues. This is meant to inhibit the damage to the epidermal laminae without disrupting the normal hoof structure.

Another completely new study will begin at The Ohio State University, where the mechanism of cryotherapy in averting laminitis will be studied and, hopefully, recreated via pharmacology.

Digital Hypothermia in Laminitis: Timing and Signaling
Dr. James Belknap, The Ohio State University--First Year
The most recent figures from a study involving the USDA and State Veterinary Medical Officers project that at any given time laminitis affects 8 of every 1,000 horses in the United States. Based on the American Horse Council survey that there are 9.5 million horses in the nation, that would indicate 76,000 horses being affected at any given time. Of those affected, the USDA survey found that 4.7% died or were euthanized, or about 3,572 deaths from laminitis annually.

The authors of this project report that “an integrated research effort over the last decade has enhanced the current understanding of the pathophysiology of equine sepsis-related laminitis (one of numerous causes of the disease). This has mirrored progression of sepsis research in human medicine by moving from (an earlier) concept . . .to determining that a marked inflammatory injury takes place and is likely to play a prominent role in tissue injury and subsequent failure.”

However, there have been persistent failure of systemic therapies for organ/laminar injury in both human and equine medicine. One advantage laminitis presents is that it effects the hoof rather than visceral organs, lending itself to artificial cooling more readily. In a present project funded by the Foundation, digital hypothermia (cooling of the hoof) prior to onset of carbohydrate overload-induced equine sepsis resulted in dramatic decrease in laminar inflammatory signaling.

The next goal is to find pharmaceutical therapies which can accomplish the same without the cumbersome aspects of maintaining constant hypothermia to the equine hoof (hooves).

Click here to easy-order the poster created with the Michigan State U. Equine Foot Laboratory

 © Fran Jurga and Hoofcare Publishing; Fran Jurga's Hoof Blog is a between-issues news service for subscribers to Hoofcare and Lameness Journal. Please, no use without permission. You only need to ask. This blog may be read online at the blog page, checked via RSS feed, or received via a digest-type email (requires signup in box at top right of blog page). To subscribe to Hoofcare and Lameness (the journal), please visit the main site, www.hoofcare.com, where many educational products and media related to equine lameness and hoof science can be found. Questions or problems with this blog? Send email to blog@hoofcare.com.
 
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Disclosure of Material Connection: I have not received any direct compensation for writing this post. I have no material connection to the brands, products, or services that I have mentioned, other than Hoofcare Publishing. I am disclosing this in accordance with the Federal Trade Commission’s 16 CFR, Part 255: Guides Concerning the Use of Endorsements and Testimonials in Advertising.

Thursday, May 07, 2009

Hoof Research Road Show Premieres This Weekend: Pollitt-Hampson Laminitis and Wild Horse Hooves Headline in Australia

by Fran Jurga | 7 May 2009 | Fran Jurga's Hoof Blog

Dr. Pollitt is known for his hoof-related research but part of his ability to get people to listen is his dazzling imagery. These images are from a series of CT scans of a foot. (©Chris Pollitt/AELRU image)

A couple of weeks ago, there was a street scene here in Boston that was wilder than anything since the Red Sox won the World Series. U2 was in the town. That's not so unusual in itself--the band might play Fenway Park or some other huge venue and sell it out for three or four nights of legendary concerts.

But this was different. They secretly booked a tiny concert hall in the suburb of Somerville.

I can remember, vaguely, that the Rolling Stones did something similar years ago. They wanted to play a small, intimate little theater where they could see the audience and judge how the music was received.

The same thing is going on this weekend in the southern end of Australia, where Dr. Chris Pollitt and his PhD candidate assistant Brian Hampson are quietly opening a new series of lectures on laminitis and hoof research. They'll be at the University of Melbourne Friday, and in Tasmania Sunday.

Dr. Pollitt's been lecturing about laminitis for years, but his work now has the added synergy of the brumby (wild horse) research component, which in turn has been energized by some out-of-the-box thinking about domestic vs wild horses that will have all of us scratching our heads when we finally hear these lectures.

Dr. Pollitt's model foot begins with a MIMICS image, created in collaboration with Dr Simon Collins, Animal Health Trust, Newmarket, UK

There were gasps of apprehension when Dr. Pollitt stepped down as professor at the University of Queensland vet school, but the research world was pleased. Freedom from teaching would surely allow him to dedicate full time to his directorship of the Australian Equine Laminitis Research Unit, the world's leading center for laminitis research at the University of Queensland.

To everyone's surprise, something else happened. In addition to charging forward on the laminitis front with a collaboration with the Laminitis Institute at the University of Pennsylvania, he started a second research center, the brumby unit, designed to study the hooves of Australian wild horses so that he could finally come to understand how a normal foot is supposed to function.

For years, Dr Pollitt has said that his hands have been tied in laminitis research because he is trying to understand a disease mechanism in the foot without being able to compare it to the normal functioning foot because we simply don't have a good model of the normal foot.

So Pollitt and his research associate, Brian Hampson, and most recently with sidekick American veterinarian Dr. Donald Walsh of Missouri, have been trekking through the outback of Australia studying wild horses in wet, dry, rocky, sandy and even flooded terrain. They watch, they film, they tag, they camp, they bring volunteer research assistants, and they've collect data--volumes of it, none of which has been shared except in tantalizing tidbits until now.

Donald Walsh DVM of Missouri, president of the Animal Health Foundation in Pacific, Missouri, has been conducting laminitis research in Australia but rode out on brumby research expeditions with Pollitt and Hampson. Walsh has been studying wild horse feet in the USA; the Animal Health Foundation helps fund Pollitt's laminitis research. (Brumby Research Unit Photo)

Marg Richardson, a research team member of the Australian Brumby Research Unit, is one of the hosts for the lecturers this weekend and has organized the warmup tour.

She is particularly excited to be introducing Brian Hampson in his first official speaking tour. At the Australian Brumby Research Unit, Hampson is undertaking world-leading research by capturing and sedating brumbies, attaching GPS collars, tracking their movement and then recording the relevant data for herd groups. This includes what they are eating, the condition of their hooves and how much they are moving.

One of the marketing projects launched by the Australian Brumby Research Unit is making freeze-dried brumby feet available to other researchers.

Maybe, it turns out, to understand a lot about hooves we need to learn to a little bit about behavior. “Never has the saying of ‘No Foot No Horse’ been more obvious, when you see how much these horses move,” Hampson says. “We have tracked the movement of domestic horses in a variety of settings from the racing environment (to) five-acre paddocks (and) up to 10,000 acre paddocks to see the variation of movement and it has been quite staggering. Old brood mares turned out in paddocks are moving more over a 24-hour period than our elite race horses."

Dr. Pollitt's presentations will center on using computed tomography imagery to share the inside view of what happens to the hoof in laminitis and other hoof diseases, compared to normal hooves. Digital images from the CT scans, arranged in 3-D will also allow manipulation of the model to observe whatever tissue is of interest. Models will be shown for laminitis, side bone and normal feet.

A world tour is planned, of course; Dr Pollitt plans to speak at the 5th International Equine Conference on Laminitis and Diseases of the Foot in West Palm Beach, Florida, to be held November 6-8. See you there.

It sounds like Brian Hampson is ready for a world tour of his own.

I am not positive that places are still open in the lectures, but you can inquire. Please email Marg Richardson or phone (in Australia) 64 272255 or 0419 572255. Click here for a press release and links to flyers from the Equine Veterinarians Australia web site.

To learn more, visit both The Australian Equine Laminitis Research Unit and the Australian Brumby Research Unit.

© Fran Jurga and Hoofcare Publishing. No use without permission. You only need to ask. Fran Jurga's Hoof Blog is a between-issues news service for subscribers to Hoofcare and Lameness Journal. This blog may be read online at the blog page, checked via RSS feed, or received via a digest-type email (requires signup in box at top right of blog page). To subscribe to Hoofcare and Lameness (the journal), please visit the main site, www.hoofcare.com, where many educational products and media related to equine lameness and hoof science can be found. Questions or problems with this blog? Send email to blog@hoofcare.com.

Tuesday, October 14, 2008

Churchill, Arlington, Calder and The Fair Grounds All Ban Toe Grabs

Trainer Steve Asmussen paid close attention to how Steve Norman was trimming his filly Pocahontas during Derby Week at Churchill Downs in 2004. (Thanks to Dan Burke of FPD for this photo.)

This press release was issued today and is printed below verbatim, so that I don't possibly misquote the fine print of what is and is not allowed. I know that this verbiage is still a little confusing, but eventually the what-is-legal-and-what-is-not parameters will sort themselves. The bold terms are mine, to help keep the main points straight.

Brief explanation of terms: Toe grabs refer to traction cleats in the toe bend of the shoe (front of foot). Currently shoes are sold with toe grabs of different heights. Turndowns refer to mechanically bending the heels of the shoe in the back part of the foot. Shoes are sold with flat heels. Turndowns usually refers to a steeper alternation of the heel and a "bend" is a minor turndown.

LOUISVILLE, Ky. (Oct. 14, 2008) - Churchill Downs Incorporated has implemented a new horseshoe policy at its four racetracks that bans the use of toe grabs greater than two millimeters. The new policy is effective immediately.

The policy, which will apply to all horses racing and training at Churchill Downs, Arlington Park, Calder Race Course and Fair Grounds Race Course, states:

"Front horse shoes which have toe grabs greater than two millimeters shall be prohibited from racing or training on all racing surfaces at all Churchill Downs Incorporated racetracks. This includes but is not limited to the following: toe grabs, bends, jar calks, stickers and any other traction device worn on the front shoes of Thoroughbred horses.

"Any hind shoe with a turndown of more than one-quarter inch will not be allowed on the dirt courses.

"Hind shoes with calks, stickers, blocks, raised toes or turndowns will not be allowed on the turf courses. This includes quarter horse shoes or any shoe with a toe grab of more than one-quarter inch."

"Our change in policy is another positive step toward improving the welfare and safety of our equine and human athletes, and it's consistent with the recommendations of The Jockey Club Thoroughbred Safety Committee, TOBA's Thoroughbred Action Committee and the Kentucky Horse Racing Commission to address safety in horse racing," said Donnie Richardson, senior vice president of racing for Churchill Downs Incorporated.

(end press release)

© Fran Jurga and Hoofcare Publishing. This post was originally published on October 14, 2008 at www.hoofcare.blogspot.com.

Fran Jurga's Hoof Blog is a between-issues news service for subscribers to Hoofcare and Lameness Journal. This blog may be read online or received via a daily email through an automated delivery service.

To subscribe to Hoofcare and Lameness, please visit our main site, www.hoofcare.com, where many educational products and media related to equine lameness and hoof science can be found.

Thursday, January 25, 2007

Barbaro Update: Cast changes, heel abscess in right hind

From the University of Pennsylvania today:

“Barbaro was placed under anesthesia yesterday to have his left hind foot cast replaced,” said Dr. Dean W. Richardson, Chief of Surgery. “We also removed the cast on his right hind leg and replaced it with a custom-fabricated plastic and steel orthotic brace to give his foot additional support.” An abscess near the lateral heel of his right hind foot was drained, and the brace that was applied will allow more regular treatment of that foot.

“Barbaro had another smooth pool-recovery and has been comfortable with an excellent attitude and appetite since then,” said Dr. Richardson. “We will probably replace his left hind foot cast under anesthesia again at least two or three times at roughly two-week intervals if his comfort is maintained. We were very pleased with the progress of his left hind foot since the last cast was applied.”

In addition, new shoes were placed on both front feet for additional support.