Palatable pergolide paste for PPID: BEVA award for Rendle presentation on clinical research into new treatment option for "equine cushings disease"

Many ponies and horses suffer from pituitary pars intermedia dysfunction (PPID), known in the past as equine cushings disease.  Among the common clinical signs of the endocrine-related condition, seen commonly in older (but not exclusively older) animals are long, non-shedding coats and chronic laminitis. PPID can, in most cases, be successfully managed by the medication pergolide mesylate, which is currently only FDA-approved in a poorly palatable tablet. A recent presentation on an alternative form of the medication has been recognized with a prize from the British Equine Veterinary Association.

Research into what may one day be a significant advance in options for the treatment of horses with pituitary pars intermedia dysfunction (PPID), once known as equine cushings disease, has received an award in the United Kingdom.

Research overview: Preventing laminitis by studying insulin dynamics in older horses

Laminitis research comes in many forms. Recently, the emphasis has been on understanding the cause of the disease, and developing ways to prevent horses from ever knowing laminitic pain. The emphasis is on understanding how horse management and feeding can effect hormonal balances in older horses, and what recommendations might help horses live longer and healthier lives.

Laminitis research: Feeding a high starch diet can influence PPID (Equine Cushings Disease) test results

Summary: New research, conducted in collaboration with the British horse feed company SPILLERS®, has shown that the equine diet, and more specifically, a starch rich food, can influence adrenocorticotropin hormone ,or ‘ACTH’, test results. This could potentially lead to an incorrect disease diagnosis in some horses when ACTH is used to test for Pituitary Pars Intermedia Dysfunction (PPID).

Key point: The threshold values for diagnosis of the disease currently vary dependent on the season, but these new findings suggest that diet should also be considered. 

Hoof Blog note: Laminitis in older horses is commonly blamed on PPID, but a definitive diagnosis by hormonal test results is required to determine if an underlying endocrine condition is the cause of laminitis. Some horses with PPID may lose weight, which might lead owners to increase feed or change to a higher-starch diet to counter weight loss. Horse owners and veterinarians should communicate about a horse's feed intake before testing; future research may reveal more specific guidelines about how feed type influences test results.

PPID: Equine endocrinology researchers revise guidelines for "Cushings" tests for horses

Equine Cushings Disease or pituitary pars intermedia dysfunction (PPID) has been easy to identify, with overt signs like a long coat. Underlying PPID is now being identified in younger horses and in horses that show none of the typical signs. Researchers say that an episode of otherwise-unexplained laminitis may be their first and only clue. 

Edited from press release

Equine pituitary pars intermedia dysfunction (PPID) can be detected earlier and more reliably with a new set of guidelines developed by the Equine Endocrinology Group (EEG), a body of leading veterinarians and researchers in the field of equine endocrinology.