Sunday, March 18, 2012

Scott Simpson: Official Obituary and Memorial Information

O F F I C I A L  O B I T U A R Y

James Scott Simpson (1933 - 2012)


On March 1, 2012, the Hoof Blog reported the death of farrier J. Scott Simpson and published a personal tribute to Scott and his role in American horseshoeing. We promised to report more details when they became officially available and today we are able to do that. We are posting here the official obituary for Scott Simpson, which appears today in the Bozeman Daily Chronicle in Montana.

Of special importance is that Scott's family has set up a memorial page for him on the Wickenburg Funeral Home web site and they would like to invite everyone who knew Scott to visit the page and record their memories. You can also upload photos of Scott to the site.


Finally, a memorial service is planned for Scott, tentatively in late May, in Bozeman, Montana. More details about that will be announced later.

This information will remain on the Hoof Blog for anyone to access at any time.

The following text is as it was prepared by Scott's family.

James Scott Simpson of Bozeman passed away February 29, 2012, but not until he'd completed nine holes of golf in the desert near his winter home in Wickenburg, Arizona.

He was born March 27, 1933 in Prescott, Arizona, to Kenneth and Helen Simpson. The family soon moved to San Diego, California, where he attended Sweetwater High School in National City. At the age of 13 he learned to fly, sometimes washing airplanes in exchange for flying lessons. In later years he became a Certified Flight Instructor.

He served as a Staff Sergeant in the U.S. Army National Guard, receiving various awards for marksmanship. He also worked in the aerospace industry at General Dynamics Aeronautics. Around this time he met and married Evelyn Moore, with whom he started a family and reared five children.

He acquired his first horse at the age of 18, which established the direction the rest of his life was to take. He became skilled first as a cowboy and rodeo rider, then as a horseshoer, graduating with his best friend Mike Williams from the California Polytechnic horseshoeing school in 1959.

After 17 years as a professional farrier, he founded the Horseshoeing School at Montana State University in 1970. He later became the instructor of farrier science at Walla Walla Community College in Washington, and at his own Northwestern School of Horseshoeing.

During this time he remained active as a horseshoer and horseman, working in virtually every activity and discipline in the horse industry, including Thoroughbred racing, harness racing, hunter jumpers, dressage horses, working cow and ranch horses, pro rodeo, and as a horse show judge.

He served as president of the American Farrier's Association, and received the AFA's Outstanding Educator, Outstanding Clinician and Outstanding Journalism awards. In 1999 he was inducted into the International Horseshoeing Hall of Fame at Churchill Downs in Louisville, Kentucky. His teaching and expertise took him to places such as Australia, Hawaii, Japan, Russia, Alaska and Canada, as well as much of the continental U.S.

He was the author of numerous books on horseshoeing, the culmination of which is his magnum opus, The Contemporary Horseshoer: Shoeing Horses in the Twenty-First Century. He also wrote numerous articles in journals and magazines ranging from Western Horseman to Plane & Pilot.

He also helped to establish certification for professional farriers, developed the "Eagle Eye" principal of shaping a horseshoe to an individual horse's foot, and invented numerous implements for farriers, horsemen, and aviators.

Scott was a man of wildly diverse interests, whose passions included tennis, golf, cross-country skiing, fly fishing, big game hunting, and music, he being a gifted singer. With the Last Chance Ranch Hands he recorded Cowboy Up, a collection of traditional cowboy songs that has enjoyed much popularity.

Scott was a passionate and devout Christian, being a member of Valley of Flowers Catholic Church in Belgrade. He refused to answer the phone while having his afternoon devotions, or while watching Jeopardy! His teaching, mentoring, generosity, humor, commitment to excellence and love, touched many hundreds of lives over the years.

He is preceded in death by his father, Kenneth Simpson; his mother, Helen; his brother, Michael, Evelyn, and great-grandson Elijah. He is survived by his five children, Mary (George) Smith, Blake (Carmen) Simpson, Ben (Corrine) Simpson, Frank (Tamilla) Simpson and daughter Howie Simpson. Scott had seven grandchildren, Megan Smith-Jones, Christina Smith, Jeffrey Simpson, Michelle Simpson, Rachel Simpson, Mercy Anna Simpson, John Scott Simpson, and great-grandsons, Brendan and Joseph Jones.

A memorial service is planned for the end of May.


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© Fran Jurga and Hoofcare Publishing; Fran Jurga's Hoof Blog is a between-issues news service for subscribers to Hoofcare and Lameness Journal. Please, no use without permission. You only need to ask. This blog may be read online at the blog page, checked via RSS feed, or received via a digest-type email (requires signup in box at top right of blog page). To subscribe to Hoofcare and Lameness (the journal), please visit the main site, www.hoofcare.com, where many educational products and media related to equine lameness and hoof science can be found. Questions or problems with this blog? Send email to blog@hoofcare.com.  
Follow Hoofcare + Lameness on Twitter: @HoofcareJournal
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Disclosure of Material Connection: I have not received any direct compensation for writing this post. I have no material connection to the brands, products, or services that I have mentioned, other than Hoofcare Publishing. I am disclosing this in accordance with the Federal Trade Commission’s 16 CFR, Part 255: Guides Concerning the Use of Endorsements and Testimonials in Advertising.

Saturday, March 17, 2012

Guinness TV Commercials for St Patrick's Day

If you can't be at a St Patrick's Day parade today, you can feel the spirit of the day with a few great Guinness commercials. It might be safer, too.

Happy St. Patrick's Day! Whatever you do today, there's a chance you might run into some of the products or culture spawned by the Guinness Brewery of Dublin, Ireland.

Friday, March 16, 2012

Cushing's Disease: Pergolide Compounding Update as FDA Issues Statement on Use of Pergolide Products for Animals

C0004P0063

 This statement may also be read on the FDA web site. This statement was posted on March 16, 2012.

On September 7, 2011, the U.S. Food and Drug Administration (FDA or Agency) approved a new animal drug application (NADA) for a product containing pergolide mesylate (NADA 141-331) marketed under the trade name Prascend Tablets for the control of the clinical signs associated with Cushing’s Disease in horses. Consistent with this approval, the Agency is announcing that it intends to consider the factors set forth in Compliance Policy Guide (CPG) Sec. 608.400 - Compounding of Drugs for Use in Animals (CPG 7125.40) in evaluating potential enforcement actions involving the compounding of pergolide products for animal use from bulk active pharmaceutical ingredient (API).


In the past, veterinarians prescribed human pergolide products to treat Cushing’s Disease in horses under the “extralabel” use provisions of the Federal Food, Drug, and Cosmetic Act. However, in May 2007, the human pergolide products were removed from the market due to concerns about cardiac side effects in humans. At that time FDA stated that it would work with the sponsors of approved human products and others to ensure that pergolide remained available to treat Cushing’s Syndrome in horses until a new animal drug application was approved for that use. FDA stated that this would include, among other things, exercising enforcement discretion as appropriate over the pharmacy compounding of pergolide for use in animals.


Consistent with our previous statement, based on the approval of Prascend, FDA intends to apply the Federal Food, Drug, and Cosmetic Act requirements regarding new animal drugs to animal drugs containing pergolide that are compounded from bulk API in accordance with CPG 608.400.

The preceding text is the message published today by the FDA.

In Monday's Federal Register, the change becomes official and the verbiage is a little more clear. It includes this summary statement:

SUMMARY: The Food and Drug Administration (FDA) is amending the animal drug regulations to reflect approval of an original new animal drug application (NADA) filed by Boehringer Ingelheim Vetmedica, Inc. The NADA provides for the veterinary prescription use of pergolide mesylate tablets in horses for the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease).

Download the full Federal Register documentation in PDF format.

Photo of pony with Cushings disease at top courtesy of University of Nottingham School of Veterinary Medicine and Science.

Order your copy of an extensive reference book on hoof rehabilitation.


© Fran Jurga and Hoofcare Publishing; Fran Jurga's Hoof Blog is a between-issues news service for subscribers to Hoofcare and Lameness Journal. Please, no use without permission. You only need to ask. This blog may be read online at the blog page, checked via RSS feed, or received via a digest-type email (requires signup in box at top right of blog page). To subscribe to Hoofcare and Lameness (the journal), please visit the main site, www.hoofcare.com, where many educational products and media related to equine lameness and hoof science can be found. Questions or problems with this blog? Send email to blog@hoofcare.com.  
Follow Hoofcare + Lameness on Twitter: @HoofcareJournal
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Disclosure of Material Connection: I have not received any direct compensation for writing this post. I have no material connection to the brands, products, or services that I have mentioned, other than Hoofcare Publishing. I am disclosing this in accordance with the Federal Trade Commission’s 16 CFR, Part 255: Guides Concerning the Use of Endorsements and Testimonials in Advertising.

Laminitis Research Highlights Grayson Jockey Club Foundation's Research Lists for 2012


The Grayson-Jockey Club Research Foundation announced today that the charitable organization will fund 16 projects in 2012, totaling $845,646. The research includes the launch of eight new projects, continuation of eight projects entering their second year, and the Storm Cat Career Development Award.

Of special interest is the announcement that a project on laminitis has received the Elastikon™ Equine Research Award. This is funded in part through a contribution by Johnson & Johnson’s Consumer Products Company, manufacturer of Elastikon tape and other equine products.

Of particular interest are the following projects:

LAMINITIS STUDIES

1. Digital Hypothermia in Laminitis: Timing and Signaling
Dr. James Belknap, The Ohio State University (Second Year)

Dr. Belknap
The most recent figures from a study involving the USDA and State Veterinary Medical Officers project that at any given time laminitis affects 8 of every 1,000 horses in the United States. Based on the American Horse Council survey that there are 9.5 million horses in the nation, that would indicate 76,000 horses being affected at any given time. Of those affected, the USDA survey found that 4.7% died or were euthanized, or about 3,572 deaths from laminitis annually.

The authors of this project report that “an integrated research effort over the last decade has enhanced the current understanding of the pathophysiology of equine sepsis-related laminitis (one of numerous causes of the disease). This has mirrored progression of sepsis research in human medicine by moving from (an earlier) concept . . .to determining that a marked inflammatory injury takes place and is likely to play a prominent role in tissue injury and subsequent failure.” However, there have been persistent failure of systemic therapies for organ/laminar injury in both human and equine medicine. One advantage laminitis presents is that it effects the hoof rather than visceral organs, lending itself to artificial cooling more readily.

In a present project funded by the Foundation, digital hypothermia (cooling of the hoof) prior to onset of carbohydrate overload-induced equine sepsis resulted in dramatic decrease in laminar inflammatory signaling. The next goal is to find pharmaceutical therapies which can accomplish the same without the cumbersome aspects of maintaining constant hypothermia to the equine hoof (hooves).

2. Laminar Energy Failure in Supporting-Limb Laminitis
Dr. Andrew Van Eps, University of Queensland (Second Year)

Dr. Van Eps
A frequent and disheartening result of injury repair is that the leg opposite the one injured develops laminitis. This is known as supporting-limb laminitis and is what eventually caused Barbaro to be euthanized. Although it is a common occurrence, the mechanisms of the malady have not been established.

Dr. Pollitt
This project is headed by a young researcher, Dr Andrew Van Eps, but the co-investigators are world renowned Drs. Dean Richardson and Chris Pollitt.

The project involves testing the hypothesis that supporting-limb laminitis is a result of reduced blood supply to the connection between hoof and bone (lamellar tissue). Further, that the blood supply in normal circumstances is encouraged by a regular loading and unloading of the legs and hooves (alternating which one is bearing the most weight). Injury to one leg interrupts that alternating pattern.

Dr. Richardson
The researchers will test the hypothesis with a state of the art, minimally invasive technique known as tissue microdialysis in conjunction with three dimensional computed tomography to develop effective methods of preventing or minimizing lamellar tissue energy failure. Comments in the Research Advisory Committee evaluations included “may well provide immediately applicable strategies to prevent supporting-limb laminitis” and “really nice grant, new idea about a devastating problem.”

Support-limb laminitis is a special area of research interest for the researchers funded by the Grayson Jockey Club Foundation. It is believed to be a unique form of the disease that is precipitated by prolonged weightbearing on one hind limb or one front limb, caused by the opposite (injured) limb's inability to bear weight after surgery or injury. Tragically, the overburdened "good" or "supporting" limb develops laminitis in this scenario. (Hoofcare + Lameness photo)

3. Laminar Signaling in Supporting-Limb Laminitis
Dr. James Belknap, The Ohio State University– First Year (2 Year Grant)

A recent USDA study indicates that approximately 1% of all horses in the USA suffer from laminitis at any given time, and approximately 5% of those animals die or are euthanized while many others remain crippled. Of the conditions which create laminitis, the development of the disease in the supporting limb of an already injured horse is one of the worst, since it is believed that 50% of those cases result in euthanasia.

The author reports that while there are hundreds of published papers in the literature about other forms of laminitis, reports on supporting-limb laminitis are restricted to clinical reports and case studies.

This project will “introduce a novel, non-painful model of supporting-limb laminitis and will allow for cutting edge bench research techniques to not only (1) test the current hypotheses on the cause of laminar failure, but also (2) provide an unbiased technique to determine the cellular events that occur . . .”

The investigator has performed a number of laminitis project for Grayson and the USDA, and has a well developed set of tools and techniques including laser micro-dissection of frozen laminar cells and an advanced “functional genomic” technique called RNA-Seq. By applying these techniques that have previously characterized laminitis caused by sepsis or metabolic syndrome to support limb laminitis, we will get our first understanding of what kind of drugs and treaments might prevent it.

This grant was selected by the board to receive the sixth annual Elastikon™ Equine Research Award.

4. Stem Cell Homing after IV Regional Limb Perfusion
Dr. Alan Nixon, Cornell University (First Year of Two-Year Grant)

Dr. Nixon
“The initial fervor associated with stem cell therapies has been tempered by mediocre clinical results,” states Dr. Nixon, long recognized as a key leader in quest to maximize use of stem cells. “More can be done, including pre-differentiation, gene-directed lineage targeting, and more efficient delivery.” This proposal will deliver by “local vein injection, to back-flow to bowed tendon and other disease conditions such as founder and traumatic arthritis.”

Transplanted cells then exert normalizing and restorative effects . . .” The long-range goal is to provide a simplified approach to stem cell therapy. We cannot do this without verification of cell homing and impact. (The project) will map stem cell distribution in the tendons, ligaments, and joints of the forelimb after direct venous injection.”

LAMENESS STUDIES

1. AAV-IRAP Gene Therapy to Prevent Osteoarthritis
Dr. Laurie Goodrich, Colorado State University (Second Year)

Dr, Goodrich
Osteoarthritis is a common affliction in horses, and current methods of treatment are effective only in reducing the pain, at best. This proposal will utilize gene therapy, which is a technique in which cells can be genetically modified or “re-programmed” to produce beneficial protein that will allow cartilage to heal. The initials in the project title stand for Adenoassociated Virus and Interluken Receptor Antagonist Protein. If cells in the joint could be re-programmed to produce IRAP, the devastating effects of joint inflammation could be halted and the progress of osteoarthritis could be reversed.

These researchers’ preliminary work utilizing AAV-IRAP suggests that cells of joints are easily re-programmed to produce beneficial protein. The aims of this project is to define the most appropriate dose of AAV-IRAP that will result in effective levels and answer the question of whether this approach can prevent osteoarthritis in the horse.

2. Investigation of Cell and Growth-Factor Dependent Tenogenesis
Dr. Martin A. Vidal, University of California-Davis (Second Year)

Dr. Vidal
The crux of this study is to test preliminary indications that a newly developed in vitro tendon/ligament culture model will prove effective at determining the optimal cell type from bone marrow, fat tissue, umbilical cord, tendons, ligaments, and muscle to use in tendon and ligament repair. The model also will allow investigators to learn the early molecular and cellular signals in tendon and ligament tissue formation.

The author states that current methods of healing result in inferior scar tissue and re-injury rates ranging from 23% to 67%. Transforming growth factor (TGF) combined with platelet rich plasma will be utilized, and tests will be done on how they affect tissue growth, strength, and composition. ”

3. Stem Generation of Equine Induced Pluripotent Cells for Regenerative Therapy
Dr. Lisa Fortier, Cornell University (Second Year)

Dr. Fortier
Stem cell based therapies are among avenues being tested with the goal of tendon cell regeneration to address tendonitis. The types of stem cells used so far may improve the structure of tendon healing, but appear to have limited regenerative ability or are limited due to potential issues of immune rejection.

The author explains that, “ . . . this proposal is to generate induced pluripotent stem cells (iPS cells) from equine adult dermal fibroblasts. iPS cells are the only stem cells that are both pluripotenent and autogenous, making them the most useful for clinical application. The expectation is that the results of the studies in this proposal will provide the first published description of the generation and characterization of equine iPS cells.” This is part of a process of testing the overall hypothesis that equine iPS cells will enhance tendon regeneration in cases of tendonitis.

Also, “the technical expertise gained in this study could be used in the future to generate autogenous iPS cells for use in equine cartilage and neuronal regeneration studies.”

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© Fran Jurga and Hoofcare Publishing; Fran Jurga's Hoof Blog is a between-issues news service for subscribers to Hoofcare and Lameness Journal. Please, no use without permission. You only need to ask. This blog may be read online at the blog page, checked via RSS feed, or received via a digest-type email (requires signup in box at top right of blog page). To subscribe to Hoofcare and Lameness (the journal), please visit the main site, www.hoofcare.com, where many educational products and media related to equine lameness and hoof science can be found. Questions or problems with this blog? Send email to blog@hoofcare.com.  
Follow Hoofcare + Lameness on Twitter: @HoofcareJournal
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Disclosure of Material Connection: I have not received any direct compensation for writing this post. I have no material connection to the brands, products, or services that I have mentioned, other than Hoofcare Publishing. I am disclosing this in accordance with the Federal Trade Commission’s 16 CFR, Part 255: Guides Concerning the Use of Endorsements and Testimonials in Advertising.

Friday, March 09, 2012

Hillside Horse Gets a Jockey...After 3000 Years, Thanks to Irish Bookmaker Prank



England's Uffington Horse is a 3000-year-old iconic carving into a chalky hillside. Was it designed by the ancient Celts as a sign to the gods, like some sort of equestrian crop circle? No one really knows. It's always been there, galloping freely across the vast clear hillsides.

Until this week, that is, when the local people woke up to find a jockey on the horse. and reins.

The amazing publicity stunt was pulled off by the Irish online gambling shop ("bookmaker") Paddy Power. We're in the final run-up to the Cheltenham Festival of National Hunt racing (steeplechasing, more or less, in US racing terms) and an annual prank was expected.

As you can see in the video, they didn't carve the soil, but rather used canvas to create the rider.

Paddy Power is known for its pranks and its controversial (and usually quite humorous) television commercials about gambling.

If you needed to end the week with a smile, this should do it.


© Fran Jurga and Hoofcare Publishing; Fran Jurga's Hoof Blog is a between-issues news service for subscribers to Hoofcare and Lameness Journal. Please, no use without permission. You only need to ask. This blog may be read online at the blog page, checked via RSS feed, or received via a digest-type email (requires signup in box at top right of blog page). To subscribe to Hoofcare and Lameness (the journal), please visit the main site, www.hoofcare.com, where many educational products and media related to equine lameness and hoof science can be found. Questions or problems with this blog? Send email to blog@hoofcare.com.  
Follow Hoofcare + Lameness on Twitter: @HoofcareJournal
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Disclosure of Material Connection: I have not received any direct compensation for writing this post. I have no material connection to the brands, products, or services that I have mentioned, other than Hoofcare Publishing. I am disclosing this in accordance with the Federal Trade Commission’s 16 CFR, Part 255: Guides Concerning the Use of Endorsements and Testimonials in Advertising.

Tuesday, March 06, 2012

Friends at Work: John Deans Is a Farrier in Maine


What makes a farrier tick? And what makes a farrier tick after 30 years on the job? Maybe it's those horses who hug you back. Maybe it's a walk on the beach with your truck dog in between barn calls. Maybe it's living in a beautiful place like Maine.

Or maybe it's just being comfortable in yourself and loving what you do every day.

I think that's what we have here.

I've known John Deans probably for as long as I've been around the hoof world. We've sat through some of the best and some of the worst lectures and clinics that the farrier associations and vet clinics in New England could organize.

Watching this video made me realize just how long that's been, and how we all get a little sentimental about our jobs when we settle in and realize we've been doing it for a very long time--because it's what we want to do and because we live where we want to live.

I have a feeling that many people could fit the template of this video, but with different landscapes behind them and different truck dogs. It's a fitting template for someone who fits right in in their environment, and is as comfortable with themselves as they are with the animals who share their days.

Technical note: If you're looking closely at what John's doing in this video, you might be confused if you're not from a snowy part of North America. He's applying what we call "snow shoes". They are standard-issue around here. It's hard to see the shoe, but the pad has a big bubble in the center that pops the snow out so that no snowballs form in the foot. The shoe might have borium (hardsurfacing) on it or tiny studs, both for traction, or John might have driven in a couple of tungsten-tipped nails that add traction.


Thanks to Emma Deans (left) for making this video. Emma is John's daughter; she recently graduated from the University of Maine at Farmington and is pursuing what will surely be an exciting career in multimedia journalism. 
You can learn more about Emma and her adventures at http://emmadeans.com/. Something tells me we'll be hearing more from her!


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© Fran Jurga and Hoofcare Publishing; Fran Jurga's Hoof Blog is a between-issues news service for subscribers to Hoofcare and Lameness Journal. Please, no use without permission. You only need to ask. This blog may be read online at the blog page, checked via RSS feed, or received via a digest-type email (requires signup in box at top right of blog page). To subscribe to Hoofcare and Lameness (the journal), please visit the main site, www.hoofcare.com, where many educational products and media related to equine lameness and hoof science can be found. Questions or problems with this blog? Send email to blog@hoofcare.com.  
Follow Hoofcare + Lameness on Twitter: @HoofcareJournal
Read this blog's headlines on the Hoofcare + Lameness Facebook Page
 
Disclosure of Material Connection: I have not received any direct compensation for writing this post. I have no material connection to the brands, products, or services that I have mentioned, other than Hoofcare Publishing. I am disclosing this in accordance with the Federal Trade Commission’s 16 CFR, Part 255: Guides Concerning the Use of Endorsements and Testimonials in Advertising.